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[DOI] [PubMed] [Google Scholar] Laron Z

[13] Animal models [edit] Knockout mice of GPX4 die at embryonic day 8 [14] [15] and conditional inducible deletion in adult mice (neurons) results in degeneration and death in less than a month

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Therefore, as an autoimmune disease, GD can cause systemic immune activation and high levels of inflammatory factors in the circulation, leading to the activation of the HPA axis and hypersecretion of related hormones