DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-PNP Size:50mg TMP-POM 7c is a trimethoprim

TMP-POM 7c is a trimethoprim (TMP)-based PROTAC (proteolysis-targeting chimera) designed to modulate protein activity through targeted degradation

84 SMILES NS(=O)(=O)C1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC2=C1NC=C2Cl Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Biotin is a high-affinity ligand for streptavidin and avidin proteins

5-TAMRA cadaverine is the purified single isomer of 5(6)-TAMRA cadaverine mixture

68 Purity (HPLC) >= 95% Physical Appearance Orange solid Optical Properties Abs/Em Maxima: 553/580 nm Solubility DMSO Shipping Conditions Shipped on gel packs Storage Conditions Store at -20°C and protected from light Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-PNP Size:50mg TMP-POM 7c is a trimethoprimSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further