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see below) to ensure complete precursor dissolution and homogeneous nucleation (Fig

Carriker all received funding from Pelame, LLC to perform this study

10.1016/j.ejphar.2007.04.038 71

Side effects are generally mild and short-lived

Beyond iron handling, NRF2 modulates the GSH antioxidant system by inducing the expression of enzymes required for GSH biosynthesis, such as glutamatecysteine ligase catalytic and modifier subunits (GCLC/GCLM), glutathione synthase (GSS), and the cystine/glutamate antiporter subunit SLC7A11 [114]