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1 : -L- ( -L- ): 1 (1000 )

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19 One study evaluating MACI with long-term follow-up (512 years) found failure rates of 18.2 and 87.5% in complex and salvage cases, respectively, compared to a failure rate of only 4.3% in less complex cases

Considering the advantages of an acidic pH and the physiological environment of the nose, intranasal formulations should ideally have a pH level between 4.5 and 6.5, which is important to avoid adverse effects on the mucosa or the ciliary movement [102]

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