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Overall, it would appear that the abundance of GSTs and their predominantly high activity with JS-K would cause the rapid biotransformation of the prodrug in most tissues

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In humans, many circadian-regulated rhythms exhibit attenuated amplitude and phase shifts in older age (Figure 2 illustrates schematically some documented changes: rhythms of locomotor activity (rest-activity cycle), core body temperature, hormone secretion (e.g., melatonin at night, cortisol in the morning), SCN neuronal firing rate, and even daily metabolic indicators like plasma glucose all show diminished oscillation amplitudes in older adults compared to younger adults

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This is likely because the product used for the injections was flawed