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2.4 Gut dysbiosis and cognitive impairment in diabetes mellitus Human gut microbial communities promote host health through reciprocal relationships between them, and gut ecological dysbiosis is characterised by a reduction in microbially dominant strains and inadequate exposure to beneficial substances leading to poor gut microbial colonisation (49)

We hypothesized that age-dependent elevation of labile iron, coupled with a reduction of glutathione levels conspire to lower the threshold for ferroptotic signaling, increasing the vulnerability of aged animals and implying that disruption to the iron-glutathione axis is fundamental to natural aging and death

*(Arginine, Citrulline, Glutamine, L-Carnitine, Lysine, and Ornithine)

doi:10.1016/S0891-5849(02)00862-6

Suresh E, Pazianas M, Abrahamsen B