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doi: 10.1111/imr.12500 23 CoulthardLGWoodruffTM

10.1016/S0016-5085(03)01215-0 14

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

But mitochondria can also the source of a lot of oxidative stress, which has been implicated in cancer, diabetes, metabolic disorders, and heart and lung diseases, among others