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Angiogenesis, collagen synthesis, neuroprotection and inflammatory modulation compounds verified for preclinical research Tissue repair is a coordinated biological process involving angiogenesis (the formation of new blood vessels), fibroblast migration, collagen synthesis, and the modulation of the inflammatory response

The first cardiovascular study of NNMT enzyme inhibition in a heart failure with preserved ejection fraction (HFpEF) mouse model demonstrated that treatment markedly reduced 1-MNA (by 77.1%), 2PY (by 66.2%), and 4PY (by 71.1%) in cardiac tissue, while improving cardiac function, enhancing global longitudinal strain, reversing peak longitudinal strain rate, and significantly reducing left ventricular hypertrophy and fibrosis

Regular monitoring of vitamin B12 levels, especially in at-risk populations, can help prevent deficiency and its associated skin issues

Muscle Weakness: Reduced muscle strength and coordination may occur

Competing interests The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported