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doi: 10.1056/NEJMra1600266

To explore gene expression changes, a multivariate reanalysis of the GSE1073233 dataset was performed, revealing major differences between untreated HepG2 and HepG2 ATP7B-KO cells, particularly in autophagy, lipid metabolism, and stress-related pathways

Our initial attempt to investigate the contribution of the TSS pathway and CBS regulation to the cysteine pool failed when cells were cultured under supraphysiological cystine concentrations