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Description

The mechanism is temperature-dependent oxidative stress: glutathione's thiol group (the sulfhydryl -SH that defines its biological activity) oxidizes spontaneously at temperatures above 8C and in the presence of atmospheric oxygen

Krijt J, Vackova M, Kozich V (2001)

5f, g), suggesting the existence of a protein complex

LDN: The most common side effects are transient and often dose-dependent

These effects were mediated through downstream activation of transcription factors including c-Fos, c-Jun, and EGR-1, which regulate genes involved in cell cycle progression, extracellular matrix remodelling, and angiogenic signalling