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For example, derivatives aimed at inhibiting targets such as COX-2, 5-LOX, or the NLRP3 inflammasome are under development, to enhance anti-inflammatory efficacy while reducing potential side effects ( 10 Conclusion As a multi-target natural compound, silybin offers novel therapeutic perspectives for inflammation-related diseases by simultaneously regulating inflammatory signaling pathways, alleviating oxidative stress, and modulating immune cell functions

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