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A NATIONWIDE ANALYSIS Shahryar Khan 1 Yousaf Zafar 2 Amina Arif 3 Muhammad Abu Bakkar 4 Azzah Muhammad Hayat 4 Mashal Alam Khan 4 , 1 University of Kansas Medical Center, 2 University of Mississippi Medical Center, 3 University of Nevada, Reno School of Medicine, 4 Khyber Medical University Background: Hepatorenal syndrome (HRS) is a serious complication of Advanced Liver Disease with high rates of morbidity and mortality

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This would result in dysfunctional lysosomes that tend to accumulate, increasing their clustering rate (Figure 6C), as previously described in APP and PSEN1 mutant neurons ( Furthermore, the higher proportion of perinuclear lysosome clusters in all our AD fibroblasts (Figures 6D, E), even more, enhanced in those with the APOE 3/4 + PSEN1 genotype could also be an indicator of lysosomal disturbance, probably by blocking the lysosomal exocytosis

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