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Simultaneously, autophagy plays a crucial role in antigen processing or presentation, which could reduce the expression of MHC class I molecules, which are abnormally downregulated in AA (50)

Any observed sleep-related effects would theoretically be mediated through GH pathway activation rather than direct CNS effects

Biochem J 1986

Subgroup analyses suggest that 12-week courses and lower daily doses (1,000 IU/day) can be effective for these endpoints, though dose-response relationships remain imprecise

Moreover, it was demonstrated that T-2 toxin induced cytotoxicity in HeLa cells is mediated by generation of ROS leading to DNA damage and trans activation of p53 protein expression which leads to shift in the ratio of Bax/Bcl-2 in favour of apoptosis and subsequent release of Cyt-c from mitochondria followed by caspase cascade [99]