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carinata was treated with 5 M CuSO 4 , the accumulation of His, threonine, Gln, glycine, Pro, and methionine was 140, 22, 7, 23, 6, and 13 M, respectively which could make about 67, 42, 45, 52, 60, and 33% complexation of 0.94 mol Cu under a pH of 5.8 (Irtelli et al., 2009)

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This process is schematically illustrated in Figure 3, which depicts how intestinal dysbiosis and LPS translocation promote hepatic inflammation via Kupffer cell activation in alcohol-exposed MASLD

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