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In general terms, spines seem to be maintained by an 'optimal' level of synaptic activity: spine density increases when there is insufficient activity, and decreases when stimulation is excessive

10.1016/j.neuron.2008.09.002 80 GreerP

It should be noted that the rate of WL with the novel pharmacotherapies could be individualised, something that is not feasible with bariatric surgery, however the optimal WL rate to optimise the risks for nutritional complications and/or cholelithiasis will need further research [107]

BPC-157 Research Peptide is a stable gastric pentadecapeptide studied through gastric mucosal models, nitric oxide signalling, angiogenesis markers, fibroblast activity and connective tissue repair endpoints