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The hallmark of T2DM is reduced mitochondrial OXPHOS capacity and decreased mitochondrial content in skeletal muscle cells and liver cells

Chronic hyperglycemia can cause macrovascular complications such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, and microvascular complications, including retinopathy, nephropathy, and neuropathy [7]

10.1096/fj.02-0092fje 57

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