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Robinson MK, Rodrick ML, Jacobs DO, Rounds JD, Collins KH, Saporoschetz IB, Mannick JA, Wilmore DW

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doi: 10.1016/j.trsl.2020.03.012, Summary Keywords aging, exercise, L-citrulline, leucine, musclevasculature, cognitive frailty, successful aging, neurovascular coupling Citation Lin X, Zhang Y, Pu J and Peng Y (2026) Targeting musclevasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention

The ischemia triggers genetic reprogramming in efferocytes [47], resulting in their proliferation, polarization, and phagocytic enhancement through the upregulation of surface receptors, extracellular bridge molecules, cytoskeletal rearrangements, and the synthesis of anti-inflammatory and trophic factors [47, 48]

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