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Filomeni et al., 2005b)

While preconditioned, short, or moderate hypoxic exposures can stimulate repair through angiogenesis, enhanced stemness, and metabolic adaptation, sustained or severe hypoxia may instead promote fibrosis, cellular exhaustion, or maladaptive remodeling [97]

Do not attempt to restart a prior protocol without a current physician evaluation your clinical picture and goals may have changed, and your physician needs to reassess

piezogenic papules) Edema in the legs in the absence of cardiac failure Mild proximal and distal muscle weakness Axonal polyneuropathy Atrophy of muscles in hands and feet Acrogeric hands, mallet finger(s), clinodactyly, brachydactyly Vaginal/uterus/rectal prolapse Dermatosparaxis EDS (dEDS) If a person meets the diagnostic criteria for dEDS, genetic testing should be done to confirm the diagnosis

Breast Cancer Res Treat 128(2):347356