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Via inhibiting metalloproteinase 1(MMP1) expression, OPs treatment markedly decreased the degradation of collagen and elastin fibers as well as recovered the altered arrangement of extracellular matrix network in the dermis of skin

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An experimental study demonstrated that the administration of metformin 500 mg/kg in mice orally for 21 days reduced oxidative stress levels and locomotor severity in MPTP-induced PD (Patil et al

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