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Intramuscular hydroxocobalamin is the preferred treatment for most patients with confirmed deficiency, particularly when malabsorption is present or neurological symptoms exist

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"2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society (in Eng)

Cyanocobalamin clears faster and requires more frequent dosing, so it has largely fallen out of routine use here

For many research protocols, particularly those involving long-term observations or where ease of administration is a significant factor, an oral compound is often the first choice