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The study sample size was significantly larger than in previous trials where Vitamin C had no significant impact on prognosis

K.RoyS.KobayashiM

Kearney LE , Brady JE, Pendergast J, Barker AM, Fix GM, Caverly TJ, Tanner NT, Tosi H, Tarren A, Do NV, Elbers D, Wiener RS

The diminished protein thiol content, susceptibility to perturbations in methionine metabolism, evidence of chronic low-grade hepatic pathology and occasional spontaneous death in mice with TR/GR-null livers suggest that homeostasis in these animals is at the brink of failure