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Pyridoxine-dependent epilepsy and antiquitin deficiency resulting in neonatal-onset refractory seizures

Since then, many small, short-term studies have reported an increased risk for biochemical vitamin B12 deficiency in patients taking metformin, with an incidence ranging from 5.6% to 36%.2-4 A large long-term study published in 2016 reaffirmed that B12 deficiency affects a small but significant proportion of patients taking metformin.5 This study analyzed data on 1,800 participants from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study who were at high risk for T2DM

Further investigation considered the planning scheme, released in 2021 with 2035 horizon

Zupo R, Castellana F, Sardone R, Lampignano L, Di Noia C, Savastano S, Giannelli G, De Pergola G

It aids the body to metabolize amino acids tyrosine and phenylalanine which help build proteins