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Proviral insertion in Murine lymphomas (PIM2), a serine/threonine kinase and a proto-oncogene [104], phosphorylates hexokinase II (HKII), which results in increased enzyme stability and activity [105]

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It has been proposed that copper may enter as anionic copper ligands (CuL) or complexed with GSH (70), possibly passing through the outer mitochondrial membrane into the intermembrane space (IMS)