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The ingredients seem to have changed since the ingredient list posted below from 2019

Nat Genet 53:16981711

Dual-target compounds for Alzheimers disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR)

The expression of the immunoproteasome 5i, which is important for the degradation of oxidized proteins under stressful conditions, was decreased in ibuprofen treated male livers relative to controls whereas it was increased in female mice livers in ibuprofen treated group