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doi: 10.1126/scisignal.abe3800 59 LuCYangDKlementJDColsonYLOberliesNHPearceCJet al

CP deficiency disrupts this process, leading to pathological Fe 2+ accumulation and subsequent ferroptosis induction ( 4.2.2 System Xc System Xc , a critical intracellular antioxidant component, is an amino acid antiporter composed of the light chain SLC7A11 (xCT) and heavy chain SLC3A2 (4F2hc), which are interconnected by disulfide bonds (Zhang G

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Manipulating the expression level of the astrocyte-specific plasma membranemicrofilament linker ezrin alters resilience to stress 147

The disruption of the antioxidant defense system was evident through suppression of enzymatic antioxidants, with CAT, GPX, and SOD showing marked inhibition