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16 : 417422 Esposti D, Mariani M, Demartini G, Lucini V, Fraschini F, Mancia M

A bidirectional link between intestinal disorders and neurodegeneration in the pathogenesis of Parkinson's disease Relevant preclinical and epidemiological studies illustrated that the occurrence of common intestinal disorders, such as colorectal cancer (CRC), constipation, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and small intestinal bacterial overgrowth syndrome (SIBO), were associated with PD by affecting the central nervous system (Barboza et al., Table 1

In all, persistent tissue injury provokes chronic inflammation and an increase of pro-fibrotic factors, such as TGF-1, ROS, PAI-1, ROCK, TNF, and TIMPs, which induce the phenotype transformation of precursor cells to myofibroblasts