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There is a lot of evidence confirming that in order to improve the value of SOD utilization, researchers have developed SOD mimics such as 2,2,6,6-Tetramethyl-4-[[5-(triphenylphosphonio)pentyl]oxy]-1-piperidinyloxy bromide (Mito-Tempol), manganese (III) meso-tetrakis(N-(2-n-butoxyethyl) pyridinium-2-yl) porphyrin (MnTnBuOE-2-PyP5+), and MitoQ (mitoquinol mesylate) to improve the membrane permeability of SOD enzyme [113,114,115,116], liposome-encapsulated active SOD protein [113], and improve its own cell transmission ability

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and overexpression of STIM1 selectively in astrocytes fully recovers astrocyte Ca 2+ activity and synaptic plasticity in this model

designed a natural nanopolymer (i.e., Apa-BSA-NPs) from HA-coated serum albumin nanoparticles for the delivery of the anti-VEGF drug Apatinib (Apa) for the treatment of DR