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The body can finally downregulate its stress response and enter parasympathetic (rest-and-digest) mode instead of remaining in sympathetic (fight-or-flight) activation

For instance, miR-21 promotes CD4 + T cell glycolysis through the PTEN/PI3K/AKT pathway, which increases the cell cycle, promotes CD4 + T cell polarization toward the Th2 phenotype, and releases the fibrogenic cytokine IL-13, which is involved in arsenite-induced hepatic fibrosis [110] (Fig

Consequently, dysbiosis may compromise hepatic immune tolerance, potentially initiating an adaptive immune response

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