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Only male mice were used in this study, and all experimental procedures were approved by the Animal Care and Utilization Committee of Xiamen University (Protocol No

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2010) for validation and/or optimization of the high-penalty parameters and charges, the energy of each system was minimized (Pan and Roux 2008) to remove any steric clashes or unusual geometry by steepest descent algorithm using the input parameter EM file (Hess et al