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The activation of the ghrelin receptor leads to an increase in intracellular calcium levels and appetite, which then alerts the pituitary gland to release growth hormone

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3) electrostatic loop mobility by anchoring it to the disulfide loop (Cys57Arg143Gly61) and barrel (His120Gly141).[ 23 , 26 , 36 ] Cuinduced conformational changes therefore augment structural stabilisation of the metalbinding and electrostatic loops elicited by Zn binding and, together with disulfide bond formation, complete hydrogenbonding networks across the dimer interface