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This finding, derived from a large, randomized, placebo-controlled phase III study, validates the NLRP3 inflammasome and its downstream effector IL-1 as critical mediators of cancer progression and promising therapeutic targets for cancer interception and treatment

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Inhibition of PERK-mediated unfolded protein response acts as a switch for reversal of residual senescence and as senolytic therapy in glioblastoma

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