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Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis

In vitro studies using endothelial cell models have demonstrated effects on fibroblast migration rates, endothelial cell tube formation in angiogenesis assays, and cytoprotective mechanisms in cell culture models exposed to oxidative and chemical stressors

When using recycled municipal water, water quality management teams need to evaluate how corrosion inhibitors from the municipal process may impact water treatment strategies for cooling tower make-up water

GPX4 is the only cellular enzyme that specifically reduces phospholipid hydroperoxides to lipid alcohols using GSH as a co-factor 4 , and inhibiting the cyst(e)ine/GSH/GPX4 axis induces the strongest cell death in most cellular contexts

90,91 Additionally, the activity of epigenetics-modifying enzymes and their cofactors, such as TET and -ketoglutarate (-KG) from the tricarboxylic acid cycle (TCA), can be influenced by abnormal metabolite levels in patients with metabolic diseases, further disrupting epigenetic regulation and exacerbating disease progression