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These results highlight the significance of our research in developing therapeutic strategies that target ferroptosis to suppress tumors exhibiting high autophagy levels

Mice were subjected to 1% pentobarbital general anesthesia (50 mg/kg intraperitoneal) on days 7, 14, and 21, respectively, and then cardiac blood and dorsal skin tissues were collected (Figure 1)

GSDME-NT-mediated pore formation was tracked by immunofluorescence microscopy using a monoclonal antibody that recognizes both full-length and GSDME-NT