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Its potential anticancer effects may be linked to the activation of the NRF2-ARE signaling pathway and its associated cytoprotective properties [155]

[24] Patients with advanced liver disease, severe kidney disease, hypertriglyceridemia, or cardiovascular conditions should consult their healthcare provider before any alcohol consumption, as these conditions may be worsened by alcohol independently of tirzepatide considerations

While serious psychiatric events were rare, mild anxiety, nervousness, and irritability appeared in 2-8% of participants during the first 4-8 weeks of treatment

Furthermore, the inhibition of Prx II was found to improve psoriatic symptoms in a mouse model of psoriasis

By anchoring further investigations within the Ferroptosis-Immune-Metabolic Axis framework, future studies can accelerate the development of mechanism-based therapies that simultaneously address oxidative stress, immune dysregulation, and metabolic dysfunction