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Moreover, time-dependent accumulation of Cu 5.4 O USNPs in the urine revealed that renal clearance is the main excretion pathway for these particles, rather than intestinal excretion (Fig

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Antioxidant and Oxidative Stress Pathways A recurring theme across Epitalon cellular aging studies is the peptides proposed interaction with cellular antioxidant defence systems, a pathway also explored through the GHK-Cu Peptide , for research including: Superoxide dismutase (SOD) activity Catalase and glutathione peroxidase expression Reduction of lipid peroxidation markers in laboratory models These pathways are relevant because oxidative stress accumulation is considered a fundamental contributor to cellular ageing across multiple experimental models

doi:10.1111/j.1365-313X.2007.03389.x