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NNMT is an enzyme that catalyzes the methylation of nicotinamide (a NAD+ precursor) and other substrates, using SAM (S-adenosylmethionine) as the methyl donor

A practical heuristic: if youre set on using a modified form, the more conservative middle-ground protocols (1 mg/day for 20 days for N-acetyl amidate, or 1-2 mg for amidate alone) sit closer to the dose math that would be theoretically equivalent to the base epithalon protocols if the modifications deliver something like 5-10x bioavailability improvement

A typical method is screening the patients for serum B 12 level

(8) Creatinine and the estimated glomerular filtration rate (eGFR) provide the baseline for judging whether kidney disease is contributing to the elevated B12

Is SOD1 loss of function involved in amyotrophic lateral sclerosis