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However, the pattern differed between individual regions and may have represented the different microenvironments or tumor cells with heterogeneous characteristics

Maternal Child Health Care China (2015) 30(25):43724

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339 Moreover, certain mitochondrial proteins that fail to be imported into the mitochondrial matrix are targeted for degradation by Doa10 in a process that depends on the presence of an N-terminal mitochondrial-targeting sequence (MTS), similar to other E3 ubiquitin ligases, such as Ubr1 and San1