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The intrinsic ability of cancer cells to tolerate and recover from this DNA damage can stem from several pathways, including anti-apoptotic mechanisms, cell cycle arrest, DNA damage repair (DDR) and nucleotide metabolism, the oxidative/electrophilic stress response to free radicals, autophagy

CrossRef The Sirtuin Network: Linking NAD+ Metabolism, Mitochondrial Function, and Metabolic Homoeostasis Ewa SzczsnyMaysiak, Valentina Schiavoni, Rossella Rotondo, Sabrina Donati Zeppa, Arianna Vignini, Eleonora Moriconi, Monia Cecati, Andrea Armani, Stefania Gorini, Roberto Campagna, Massimiliano Caprio Diabetes/Metabolism Research and Reviews.2026;[Epub] CrossRef VEGFB promotes adipose tissue thermogenesis by inhibiting norepinephrine clearance in macrophages Lei Wang, Jing Jin, Nuo Zhang, Yan Dai, Xueya Bai, Jinhao Li, Yueqi Yu, Xiaoling Shi, Hui Bai, Qing Yang, Bin Jiang, Jingjing Ben, Hanwen Zhang, Xiaoyu Li, Qi Chen, Xudong Zhu Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2025

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87 Currently, the topoisomerase I inhibitor irinotecan, an analogue of camptothecin, is used to treat metastatic colorectal cancer