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Abbreviations PH: Pulmonary hypertension BMPR2: Bone morphogenetic protein receptor type II E2: Estradiol CYPs: Cytochrome P450s UGTs: UDP-glucuronosyltransferases 2-OHE2: 2-Hydroxyestradiol 4-OHE2: 4-Hydroxyestradiol 2-ME2: 2-Methoxyestradiol HSD17B: 17-Hydroxysteroid dehydrogenase 2-ME1: 2-Methoxyestrone 16-OHE: 16-Hydroxyestrone ER: Estrogen receptor PASMCs: Pulmonary arterial smooth muscle cells PAECs: Pulmonary arterial endothelial cells EndoMT: Endothelial mesenchymal transition ROS: Reactive oxygen species Nrf2: Nuclear factor E2-related factor 2 PPAR: Peroxisome proliferator-activated receptor HIF: Hypoxia-inducible factor SSc: Systemic sclerosis PAH: Pulmonary arterial hypertension ECs: Endothelial cells TGF-: Transforming growth factor- IL: Interleukin TNF: Tumor necrosis factor SMCs: Smooth muscle cells HASMCs: Human aortic smooth muscle cells GPR30: G protein-coupled receptor 30 GSTP: Glutathione S -transferase P COPD: Chronic pulmonary obstruction disease IGF: Insulin-like growth factor References Mocumbi A, Humbert M, Saxena A, Jing ZC, Sliwa K, Thienemann F, Archer SL, Stewart S

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By encouraging the proliferation and migration of pig trophoblast cells (PTr2) through its target gene phosphofructokinase-M (PFKM), miR-92b-3p can regulate embryo implantation (Wang et al., 2022c)

Side effects such as nausea and diarrhea are frequent but generally tolerablemost people hold the course

Wet hair will dilute the topical concentration and could negatively affect absorption