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These markers included increased plasma alanine and lactate levels and the presence of organic acids, such as 3-methyl-glutaconic and dicarboxylic acids, and Krebs cycle intermediates, in the urine of these patients [69]

Cell 114 : 673688 Du C, Fang M, Li Y, Li L and Wang X (2000) Smac, a mitochondrial protein that promotes cytochrome c -dependent caspase activation by eliminating IAP inhibition