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Figure 12 4 Discussion This study integrates genetic causal analysis, single-cell RNA sequencing, and bulk transcriptome analysis to elucidate the metabolic and immunological associations of glutathione in lung adenocarcinoma, particularly its effects on T cells within the tumor microenvironment

Conversely, -syn dysregulates iron homeostasis: it exhibits ferrireductase activity, reducing Fe 3+ to Fe 2+ and elevating labile iron levels, while its overexpression redistributes iron to perinuclear inclusions

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The identified species-specific metabolites also suggest that caution should be exercised when extrapolating animal experimental data to humans, providing valuable references for future translational research