Blastomyces adhesin 1 (BAD1), the most important virulence factor in Blastomyces dermatitidis , also plays an important role in complement evasion by occupying C3 sites on cell wall glucans and thus avoiding C3 deposition (Zhang et al., 2001)
In order to demonstrate the efficacy in this subgroup, a second trial including 137 subjects in early stages of ALS was conducted
The other outcome from the audit was that patients were under investigated and the aetiology of the B12 deficiency was not fully ascertained

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Neurogastroenterol Motil 2010;22:13031307