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Data represent mean SEM

Primary injury is usually generated by the hematoma after cerebral hemorrhage (Green et al., 2021), and the severity of the injury is linked with the size, location, and extent of the hematoma (Zheng et al., 2022)

Furthermore, pharmacological blockade of catalase or Nrf2 activity intensified ethanol intoxication in mice, and 28.2 M /kg/day SF (a potent Nrf2 inducer) treatment for 5 days, attenuated these effects (55), leading the studys authors to suggest that Nrf2 activation may serve as a potential therapeutic strategy for preventing acute alcoholism by regulating catalase-mediated ethanol oxidation

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This occurs through activation of the HBx/SWELL1/arachidonic acid signaling axis, with HBx and SWELL1 upstream and arachidonic acid as a downstream effector