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Chapter 3 Glucuronidation Dependent Toxicity and Bioactivation ScienceDirect Glucuronidation Part 1 YouTube Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation Definition, Examples & FAQs JoVE Core Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial Confident characterization and identification of glucuronide metabolites using diagnostic fragments from electron activated dissociation (EAD)

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