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PMID: 36430983

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The eligibility criteria for most FDA-approved weight loss drugs are as follows: Body mass index (BMI) of 30 or higher (classified as obesity) Body mass index (BMI) of 27 or higher (classified as overweight) with one weight-related health condition, such as hypertension, hyperlipidemia, heart disease, and high blood cholesterol levels

Hypoxia, which is found in a group of physiological and pathological conditions, can affect multiple cellular functions by activation of the hypoxia-inducible factor (HIF) signaling and other mechanisms