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Toxicol Sci 137:12

All randomized participants received at least one dose of the study drug and were included in both the full and safety analysis populations [1]

When the body becomes dehydrated, several functions may be affected: Circulation may become less efficient Energy levels may decrease Physical performance may be reduced Immune cells rely on the bloodstream to travel throughout the body & respond to potential threats

Weiskirchen et al., 2023)

This may mediate activation of perivascular Ms, microglia, and astrocytes, and initiate further immune responses within the brain parenchyma, suggesting neuroinflammation can be triggered by signaling from the periphery, without primary injury or disease originating within the CNS