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Neurotoxicology 31 (6), 694700

& Nohara, N

A dose-dependent effect has also been observed, with a 7% increase in the overall risk of death for every five pack-years increase in smoking history [113]

Rather surprisingly, this suggests that the benefits of reduced mTORC1 signaling, and increased autophagy may be mediated primarily by an A-independent mechanism and moreover, previous studies have demonstrated that mTORC1 inhibition leads to the suppression of tauopathy 65,66