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Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation

Gauthier et al

This is mechanistically different from opioid-induced constipation or magnesium deficiency

A: Alternatives to estradiol patches include FDA-approved transdermal gels and sprays, oral estradiol (with a different clot-risk profile), vaginal estrogen preparations for genitourinary symptoms, and compounded transdermal estradiol creams from PCAB-accredited pharmacies