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Under normal conditions, SQSTM1 recruits -synuclein to form aggregates and eliminates them through autophagy

10.1016/j.yrtph.2020.104721 48 GilmourN.ReynoldsJ.PrzybylakK.AleksicM.AptulaN.BaltazarM

Therefore, they designed an ACAT2 siRNA/chitosan (CS)-poly(lactic-co-glycolic acid) (PLGA) NPs system, composed of PLGA-block-PEG to achieve intestinal delivery and ACAT2 inhibition