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It has been revealed that thyroid cell lines that express both BRAF and RET/PTC can provoke genes that encode immune system response molecules, such as chemokines, which are pivotal for the early stages of HT lymphocytic infiltration

14,16 High iodine intake has been shown to provoke autoimmunity in animal models with a predisposition, and this corroborates the epidemiological data demonstrating a high incidence of Hashimotos thyroiditis and earlier onset of Graves disease in regions of high iodine intake

In the case of a severe and progressive condition with acute exacerbations, treatments may be administered every few days or even twice daily for best results

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10.1016/j.pmpp.2013.08.005 95 LiaoW.JiL.WangJ.ChenZ.YeM.MaH.et al